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Tumor vaccines targeting neoantigens mainly include nucleic acid, dendritic cell (DC)-based, tumor cell, and synthetic long peptide (SLP) vaccines. The combination with immune checkpoint inhibition therapy or radiotherapy and chemotherapy might achieve better therapeutic effects. Currently, several clinical trials have demonstrated the safety ...Improvement of risk stratification through prognostic biomarkers may enhance the personalization of cancer patient monitoring and treatment. We used Ancer, an immunoinformatic CD8, CD4, and ...

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The genetic instability underlying neoplastic transformation can also provide tumor-specific targets for host T cells (1–4).These include function-altering mutations in so-called “driver” genes, which endow the tumor with growth and survival advantages, as well as tumor-specific variants of “passenger” genes that lack an obvious protumorigenic …

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